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�7����:�l�����*]���,���,}���-��)�א����YM�`�oŷҦ,+~si�R����/+8U In 1981, the OECD adopted Test Guideline 403 (TG 403) (OECD, 1981), which describes how to perform a traditional acute inhalation LC50 study. �Y9�)�Rl��%� D��u�T? 1 0000006272 00000 n
This Test Guideline (TG) is based on the International Life Science Institute (ILSI)-Health and Environmental Sciences Institute (HESI), Agricultural Chemical Safety Assessment (ACSA) Technical OECD Guidelines for the Testing of Chemicals are a set of internationally accepted specifications for the testing of chemicals decided on by the Organisation for Economic Co-operation and Development (OECD). 2012-10-22T10:27:39-04:00 0000006211 00000 n
They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical …
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OECD/OCDE 425 Adopted: 17th December 2001 OECD GUIDELINE FOR TESTING OF CHEMICALS Acute Oral Toxicity – Up-and-Down Procedure INTRODUCTION 1. 2012-10-22T10:27:39-04:00
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1 0 obj <>stream In 1998 a revised version was adopted, to obtain additional information from the animals used in the study, based on the outcome of an OECD Consultation Meeting of Experts on Sub-chronic and Chronic Toxicity Testing held in Rome in 1995 (1). Ҹ���_b�n~C����ET�j���ϊk*;���K�����`�_]��)����W���@�ALOR��bl�x�oM�¨}X�)����"aT#�w}��Jk��o��d�),%��� Acute Inhalation Toxicity - Acute Toxic Class Method INTRODUCTION 1. 0000004205 00000 n
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They were first published in 1981. H�b```f`�X������� Ȁ ��@Q��� �����p�Z�&�� 2012-10-03T13:44:03+02:00
OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. H�l����0������V{ �M�H(��js�v�����C�T�j߾��ΊJ����?f>2���S�]�L�;��.����69��vA�J��-��T��Q���>/ܟB;�Q�k�9/ӻ~x9��}������ס����=���1y��p�o��Ϸq��=�E�B�t��ݎ϶�8���I���. Development of a 0000014447 00000 n
CONTENTS 2 INTRODUCTION TO TOXICOLOGY OECD GUIDELINE FOR ACUTE ORAL TOXICITY LD50 LD50/LC50 Methods to calculate LD50 Limitation of LD50 How OECD GUIDELINES More Humane? 0000004778 00000 n
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This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
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OECD Guidelines for the Testing of Chemicals (TGs) are periodically reviewed in the light of scientific progress, changing assessment practices and animal welfare considerations.
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