As long as milestones are being met and these three high-profile founders stay on board, investors should be willing to throw more money at the company until the full potential is realized. That would have been last March when we wrote about A Few Updates on the Progress of Gene Editing noting that “with patents being filed and issued left and right, it’s also starting to look like there is no single gene-editing platform that will rule them all, but rather a bunch of people doing similar things, each method having its own competitive advantage.” The following month, we wrote about 6 CRISPR Applications from Healthcare Startups which looked at how gene editing is being used in healthcare – from fighting cancer and infectious disease to discovering diseases and even new drugs. In 2018, Beam Therapeutics burnt through around $45 million, and through the first 6 months of this year, another $31 million. Beam Therapeutics says that existing gene editing methods like CRISPR, Zinc Finger Nucleases, ARCUS, and TAL Nucleases “lack control of the editing outcome, have low efficiency of precise gene correction, and can result in unwanted DNA modifications.” Those thoughts are echoed in an article last year by New Scientist titled CRISPR gene editing is not quite as precise and as safe as thought which raised safety concerns about existing methods while claiming that base editors that alter specific DNA letters “may prove to be far safer.” Earlier this year, Sangamo’s stock sunk 30% as the company’s gene therapy which uses zinc-finger nuclease technology flunked early clinical tests. It’s pretty much a given that early stage drug development efforts don’t generate meaningful revenues now, and won’t for a while. Beam Therapeutics has a portfolio of twelve therapies based on their technology that they hope will result in an “initial wave of IND filings beginning in 2021.” Their initial focus is in hematology, oncology, and immunology, and diseases of the liver, eye, and CNS. Beam Therapeutics IPO Raises $180M After Nearly Doubling Shares Offered. Trading kicks off today. It’s easy to see the potential of the technology, but not so easy to see a path to making money from it. Your email address will not be published. Also called “point mutations,” incorrect single letters are responsible for approximately 58% of genetic errors associated with disease. Seems likely that the founders of Beam Therapeutics would have taken notes from the last gene editing intellectual property battle and made sure they covered all the bases this time around. Find out which 30 dividend growth stocks we're holding in our report -. Beam Therapeutics has obtained “exclusive licenses from Harvard University, Broad Institute of MIT and Harvard, Editas Medicine, and Bio Palette,” that cover their base editing technology. One of the companies in that article, Beam Therapeutics, has just filed for an IPO. It’s such a complex question that even the company doesn’t know the answer. A Few Updates on the Progress of Gene Editing, 6 CRISPR Applications from Healthcare Startups, CRISPR gene editing is not quite as precise and as safe as thought. Beam Therapeutics is seeking a highly talented and motivated Head of Chemistry with expertise in oligo synthesis, nucleic acids and Read More. Sarah de Crescenzo. Beam Therapeutics acknowledges that “the extensive patent filings related to CRISPR and Cas make it difficult for us to assess the full extent of relevant patents and pending applications that may cover our base editing platform technology.”. If we misspelled a single letter in a word, base editing would allow us to change the letter while CRISPR would only allow us to change the entire word.
March 18, 2020 Scientist I/II, In Vivo Liver Biology. Beam Therapeutics is looking to raise $100 million through their initial public offering and it’s expected that they’ll need to continue raising lots more cash as they look to move their product portfolio to commercialization. The Beam Therapeutics S-1 filing clearly spells this out by stating “other gene editing technologies may be discovered that provide significant advantages over base editing.” No matter how exciting any disruptive technology may sound, only time will tell if it turns out to be the next Illumina or the next Bind Therapeutics. This field is for validation purposes and should be left unchanged. Assuming the IPO proceeds as planned, Beam Therapeutics will offer investors a second chance to own a next-generation gene editing technology … “If existing gene editing approaches are ‘scissors’ for the genome, our base editors are ‘pencils’ erasing and rewriting one letter in the gene,” says Beam Therapeutics. When looking at the founding team of Beam Therapeutics, we see that all three co-founders – Feng Zheng, David Liu, and Keith Joung – were also co-founders of CRSPR pioneer Editas Medicine (EDIT) and licensed their own intellectual property to the company. Cash on hand today is around $128 million. ET on Seeking Alpha. General Information: Business: We are a biotechnology company committed to creating a new class of precision genetic medicines based on our proprietary base editing technology, with a vision of providing life-long cures to patients suffering from serious diseases. We can remove fatal defects and enable optimal traits in plants, animals, and humans. February 6th, 2020. Founded in 2017, Massachusetts startup Beam Therapeutics has taken in $222 million in funding so far to develop a technology called “base editing” which focuses on precision gene-editing which replaces single letters (C, T, G, A) without inducing a double-strand DNA break.
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