The first pattern consists of aggregates of closely packed neoplastic follicles, often enlarged, that disrupt the splenic architecture and frequently show an interfollicular proliferation of neoplastic B cells. In the remaining 4 cases, a diagnosis of FL had been previously established 1, 3, 96, or an unknown number of months before splenectomy. Three distinctive subgroups were identified based upon the existence of breakpoint 3q27, a translocation t(14;18), or the absence of both. Nat. In a subtype-specific genomewide association study of non-Hodgkin lymphoma susceptibility, Skibola et al. The cases with 3q27 abnormalities or other unrelated translocations are probably more closely related to the majority of DLBCLs of germinal center cell origin. (1988) found immunoreactive BCL2 (151430) protein in the neoplastic cells of almost all follicular lymphomas, whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. eds. Over 90% Molecular analysis was performed in 28 cases. It is possible that at least some of the purely intrafollicular cases in this series represent the histologic counterparts of premalignant proliferations of IGH/BCL2+ germinal center cells that have not yet acquired a secondary abnormality required for development of overt lymphoma. Criel In all cases with available archived material, FISH was performed on intact 5-μm sections using a dual-color, dual-fusion IGH/BCL2 probe (Abbott Molecular, Abbott Park, IL) as previously described in detail.12 Briefly, slides were baked overnight at 60°C, deparaffinized, and subjected to Proteinase K treatment. In the present study, similar findings were observed. Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma. A large number of different structural aberrations were found, and these were present relatively more often in the t(14;18)-negative group than in the t(14;18)-positive group. Increased numbers of interfollicular B cells were identified by immunohistochemical analysis for CD20 in 5 of 6 AA cases, whereas the 6 AP cases each showed only scattered interfollicular or red pulp B cells. Follicular lymphoma: evolving therapeutic strategies. Bende Get the latest research from NIH: https://www.nih.gov/coronavirus. New Eng. Conde et al. (1982) found a translocation between chromosomes 18 and 14 in 16 of 19 patients with follicular lymphomas, one of the most common forms of B-cell neoplasia. [PubMed: 23246294] [PubMed: 2965608] In contrast, the second pattern consists of only scattered neoplastic germinal centers with an entirely intrafollicular growth pattern and retention of the overall splenic architecture. doi: 10.1634/theoncologist.2019-0138. [Full Text], Liu, Y., Hernandez, A. M., Shibata, D., Cortopassi, G. A. From this series, 32 successive cases in 30 patients with the histologic diagnosis of centroblastic lymphoma, follicular or FL grade 3B were selected and studied in further detail. [Full Text: https://www.nejm.org/doi/10.1056/NEJM198211113072002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed]. Teruya-Feldstein Frontlinetherapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Genome-wide association studies are helping to elucidate the role of genetic diversity in the etiology of various NHL subtypes, including FL, and to identify susceptibility variants in human leukocyte antigen (HLA) class 1 and 2 regions that may predispose lymphocytes to acquiring hallmark translocations. 92: 126-130, 2013. M [Full Text: http://www.pnas.org/cgi/pmidlookup?view=long&pmid=12571354], Conde, L., Bracci, P. M., Richardson, R., Montgomery, S. B., Skibola, C. F. Katzenberger T, Lohr A, Ott MM, Kalla J, Rosenwald A, Müller-Hermelink HK, Ott G. Best Pract Res Clin Haematol. The diagnosis and classification of small B-cell lympho-proliferative disorders in splenectomy specimens is frequently challenging. In a study of 71 patients with follicular lymphoma, Yunis et al. et al. 91: 8910-8914, 1994. Variation in gene expression patterns in follicular lymphoma and the response to rituximab. [PubMed: 2648153, related citations] USA.gov. Acad. NCI CPTC Antibody Characterization Program. J. Hum. Follicular lymphoma (FL) is typically disseminated at initial diagnosis, and there is frequent splenic involvement. Biopsy material obtained between 1983 and 1998 for the diagnosis and treatment of patients with lymphoma in Groningen, The Netherlands and Edmonton, Canada forms the basis of this study. (1982) found a translocation between chromosomes 18 and 14 in 16 of 19 patients with follicular lymphomas, one of the most common forms of B-cell neoplasia. (2003) analyzed the patterns of gene expression in follicular lymphomas from 24 patients and concluded that 2 groups of tumors could be distinguished. 1, 2 It is a B-cell lymphoma derived from germinal center B lymphocytes that overexpress the antiapoptotic protein BCL2 as a result of a t(14;18)(q32;q21) translocation between the IGH and BCL2 genes in most cases. CD20-negative DLBCL transformation after rituximab treatment in follicular lymphoma: a new case report and review of the literature. In contrast to the homogeneous appearance of … Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma? Science 237: 175-178, 1987. Integrating GWAS and expression data for functional characterization of disease-associated SNPs: an application to follicular lymphoma. Bellesso M, Nicioli LP, Menezes Y, Santucci R. Hematol Transfus Cell Ther. Oligonucleotide clonospecific probes directed against the junctional sequence of t(14;18): a new tool for the assessment of minimal residual disease in follicular lymphomas. Ardeshna KM, Qian W, Smith P, et al. [PubMed: 3287162, related citations] In 3 cases, we found discrepancies between 3q27 aberrations by cytogenetic analysis and bcl-6 rearrangements in SB. 2016 Nov 1;8(1):e2016060. (2013) identified a hexa-allelic amino acid polymorphism at position 13 in exon 2 of the HLA-DR beta chain that showed the strongest association with follicular lymphoma within the major histocompatibility complex (MHC) region (multiallelic p = 2.3 x 10(-15)). 318: 1638-1644, 1988. J [PubMed: 23791106, related citations] In the 12 cases with FL initially diagnosed in the spleen, 6 displayed the AA pattern and 6 the AP pattern. Follicular lymphoma (FL) is an indolent disease, but 30-40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by diffuse large B cell lymphoma (DLBCL). DNA was digested with 2,EcoRI, HindIII, and partly 4,EcoRI, HindIII, BamHI, andBglII restriction enzymes: Two different bcl-2probes (major: MBR2.5 and minor: PFl2), the JH6 IgH gene, and 3 different bcl-6 probes (pGSc4.0, p486a, and p4860) were used for hybridization.
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